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In patients in whom the major therapeutic goal is the compelling need to minimize the therapeutic risk pf hypoglycaemia, DPP-4 inhibitors are recommended as second line therapy after metformin failure at the same level as second line treatment options with GLP-1 receptor agonists, SGLT-2 inhibitors, or TZDs

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In cases of maintenance treatment, rituximab is often strategically administered just before conception or in the first trimester ( Belimumab, a novel BAFF inhibitor recently introduced, has undergone studies during pregnancy