They should not be used by patients with a history of pancreatic issues, certain liver conditions, thyroid cancer, or pancreatic cancer, as use of the drug can exacerbate these conditions, Tavakol says
Insomnia and sleep disturbances are not listed among the common adverse reactions for tirzepatide in the FDA-approved prescribing information for either Mounjaro or Zepbound
Animal studies provide compelling evidence for transgenerational inheritance of reproductive dysfunction through epigenetic mechanisms, though human evidence remains limited
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Both Nirchi and Long point to things like nausea and constipation, particularly when starting the drugs or titrating up to a higher dose (but for them, the benefits have outweighed the downsides)