doi: 10.3748/wjg.v29.i17.2701 161 SharmaMDPacholczykRShiHBerrongZJZakhariaYGrecoAet al
These data on patient cohorts were then used for gene-expression profile analysis, pathological stage-plot analysis, multiple gene-comparison analysis, and gene-correlation analysis using the GEPIA online tool (Affymetric id/Gene symbol: GPX4, glutathione Synthetase (GSS), Kelch like ECH associated protein 1 (KEAP1), sequestome 1 (SQSTM1), solute carrier family 7 member 11 (SLC7A11), autophagy related 5 (ATG3), ATG5, and ATG4D) [24]
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PMID: 31267972
Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)
