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GLP-1 drugs have also been linked to gastrointestinal issues, the most severe of which include bowel obstruction and stomach paralysis, but these side effects are rare and are currently listed on the drugs labels

Monitoring and titration If you are microdosing GLP-1 medications, it is important to track the side effects carefully, particularly gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation

revealed a nonsignificant improvement in headache

Additional risks include diabetic retinopathy complications (particularly with semaglutide in patients with pre-existing retinopathy), acute kidney injury (especially with volume depletion from gastrointestinal effects), and rare cases of intestinal obstruction or ileus

Participants were assigned to receive weekly doses of retatrutide at 1 mg, 4 mg, 8 mg, or 12 mg for 48 weeks, or placebo