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Intriguingly, Dichtl et al

( C ) Schematic of IRI protocol and ( D ) percentage of LVDP recovery of isolated WT mouse hearts with the sAC inhibitor KH7 (20 mol/L) or the tmAC inhibitor Ddox (50 mol/L) prior to perfusion with buffer only (Cntl), scrambled(2836), GLP-1(2836), or GLP-1 ( n = 3/group)

Morning cortisol peaks (the cortisol awakening response) occur between 69 AM in most people

In CIRS patients, whose detox pathways, mast cells, and inflammatory responses are already in overdrive, this extra stimulus can easily tip the balance into symptomatic flare

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