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Cell Death Differ 1998, 5 (7), 551562

Researchers also found no difference in hepatobiliary or gastrointestinal severe adverse events between the semaglutide and placebo groups in any obesity class

[7] Riedl E, Pfister F, Braunagel M, Brinkktter P, Sternik P, Deinzer M, Bakker SJ, Henning RH, van den Born J, Krmer BK, Navis G, Hammes HP, Yard B, Koeppel H, Linn T

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It is also noteworthy that central GLP-1R signaling appears to be impaired in chronic stress conditions or under the influence of a high concentration of glucocorticoids, often observed in patients with depression