The trade-off is that daily injections require more discipline and create more opportunities to miss doses, which can reduce effectiveness
involving patients without DM reported the OR for weight reduction of 5%, 10%, 15%, 20%, and 25% with tirzepatide compared with placebo as follows: 21.14 (95% CI: 12.6435.35), 20.03 (95% CI: 12.4732.17), 23.61 (95% CI: 13.4641.41), 26.52 (95% CI: 14.6947.88), and 26.67 (95% CI: 18.2538.96) [15]
Am J Clin Nutr 1991;54:814-20
Many patients experience renewed weight loss momentum following each dose increase, particularly during weeks 2 through 3 after stepping up their injection strength
(PubMed) Abel MH, Caspersen IH, Meltzer HM, et al
Dropping below 1,200 calories daily is generally not recommended, even on semaglutide, because inadequate intake can slow metabolism, drain energy, and trigger nutrient deficiencies