doi:10.3389/fnins.2022.909833
Y.PolyakovN
Chemical Name: PT-141 (Bremelanotide) Molecular Formula: C50H68N14O10 Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH Research Applications: Melanocortin receptor pathway studies Sexual arousal mechanism research MC4R receptor binding analysis Libido and sexual function studies Central nervous system arousal pathway research Hypothalamic activation studies Sexual behavior neurobiology protocols Product Specifications: Form: Lyophilized powder Purity: High purity research grade Molecular Weight: 1025.2 g/mol Storage: Store at -20C, protect from light and moisture Reconstitution: Use bacteriostatic water (not included) Stability: 24 months when stored properly, 30 days once reconstituted Research Background: PT-141 (Bremelanotide) is a synthetic peptide analog of -MSH that acts as a non-selective agonist of melanocortin receptors, particularly MC1R and MC4R
The dogs were divided into 3 groups depending on the received dose, including the following 3 doses: 0 mg/day 236 mg/d 492 mg/d Each group was further divided into two subgroups, receiving either 110% or 120% of their Maintenance Energy Requirement (MER), which was evaluated in a metabolic chamber at baseline
PMID: 52 AbrahamMLakMAGurzDNolascoFOMKondrajuPKIqbalJ
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