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trial, subjects receiving weekly doses of 30 to 60 mcg/kg (roughly 2,000 to 4,000 mcg for an 80 kg adult) showed sustained IGF-1 elevation with no serious adverse events over the study period (Teichman et al., J Clin Endocrinol Metab 2006)
The second order rate constant for the first phase depended on the PfGrx variant and was as high as 4.3 10 7 M 1 s 1 for roGFP2 WT -PfGrx WT
The use of GSH precursors like N-acetyl cysteine, enhancers of nuclear factor erythroid 2-related factor 2 (Nrf2) like sulforaphane, melatonin, and many more molecules involved in antioxidant defense were proposed as supplementation of other idiopathic pulmonary fibrosis therapies (130)