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Preventing Complications of Insulin Therapy Insulin administration can sometimes lead to local and systemic allergic reactions, with local reactions causing redness, swelling, tenderness, and wheals at the injection site

In these cases, we turn to immunosuppressant drugs

In another hand, while most reports appear to implicate IGF-I as a potential mediator of pathological changes in the diabetic kidney[364, 365], IGF-I is also protective against oxidative stress and apoptosis induced by high levels of glucose in cultured mesangial cells

Am J Dermatopathol 31, 107116 (2009)

Fontana RJ, Hayashi PH, Gu J, et al

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