Though the biological relevance of CIRTs is still largely unknown, their abundance in neuronal dendrites (and also in enucleated platelets) suggest that endogenous cytoplasmic transcripts harboring retained intronic substrates could be subject to extranuclear splicing, thereby obviating the need for shuttling molecules to and from the nucleus for processing (Buckley et al., In this order of ideas, it is tempting to speculate that CIRT in Gpx4-I gene may be part of the normal endogenous post-transcriptional regulation pathway
Neurobiology of Aging 25, 1253-1262CrossRefGoogle ScholarPubMed 146Schipper, H.M
Synthetic progestins work differently
Abbott Laboratories, D
References & Links Erdman, J.W., Ford, N.A., Lindshield, B.L
Based on contemporary research, more dieticians recommend supplementing B12 when a blood test shows a level less than 350 pg/mL