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Key Takeaway: Bioavailability is the difference between a supplement that simply passes through your system and one that actually reaches your cells

prausnitzii and reported that its administration markedly mitigated intestinal inflammation, reinforced epithelial barrier function, sustained regulatory T-cell responses, limited Th17-driven immunity, and attenuated the release of inflammatory cytokines 82

In other words, dont immediately go for the highest dose you can find

Although there were a variety of study parameters, the researchers specifically noted the benefits of creatine supplementation for headaches