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Peters, MO, can be a practical tool

In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis

Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

An alternative GH-pathway approach is sermorelin for fat loss, which works through a similar GHRH mechanism at lower cost

Food and Drug Administration, and are not intended to diagnose, treat, cure, or prevent any disease

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