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DOPE is often conjugated with cholesteryl hemisuccinate (CHEMS), forming a stable bilayer at physiological pH that becomes destabilized in acidic environments, such as endosomes or the tumor microenvironment, thereby promoting membrane fusion and facilitating drug release [83]

The transient receptor potential (TRP) channels on the cell surface allow Ca 2+ influx to initiate the NF-B-dependent inflammatory responses, which can be triggered by environmental irritants such as inflammatory cytokines and pathogens [61,62,63]

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