Endocrine Practice, 28(10), 923-1049
As DC processes and presents antigen to B and T cells, one of its main functions is to guarantee that the right kind and intensity of immune response is triggered
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Two other melanocortin ligands have been identified, in this case encoded by individual genes, agouti related neuropeptide (AGRP) and agouti signalling protein (ASIP)
Heme and hemoglobin degradation products catalyze reactive oxygen species (ROS) generation, whereas damage-associated molecular patterns activate Toll-like receptors on microglia and astrocytes, driving inflammatory cascades