51 The dose/concentration employed, the selected target tissue, the experimental models, as well as medicational interactions that may have positive or negative effects on the bodys redox state all influence the promotion of antioxidant effects by retinoid compounds in cell lines or living organisms
The ROS scavenging property of Sp was also replicated in the Drosophila models knocked-down for essential antioxidant enzymes catalase and glutathione peroxidase, where neuronal cells of 15 days AEL flies genetically expressing a redox biosensor, roGFP showed reduced fluorescence under Sp treatment (Fig
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Lutter contre les effets des radicaux libres
49 therefore suggested an important role of the residue as a gatekeeper to modify the reactivity of reducing or alkylating agents
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