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however, while this action can cause a risk for metabolic acidosis, this mechanism does not appear to be involved in the anticonvulsant action of the drug

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(2)Fmoc-Leu-Val-WangResin (2) Preparation of Fmoc-Leu-Val-WangResin (1)Fmoe-Val-WangResin(20DMF)5203DMF3DMF2Fmoc-Leu-OH 0.7gDIEA0.4mlTBTU0.56gHOBT0.2gDMF10ml1.53DMF3DMF2Fmoc-Leu-Val-WangResin In the Fmoe-Val-WangResin of step (1), add decapping reagent (DMF solution of 20% piperidine), react at room temperature for 5 minutes, drain, add decapping agent at room temperature and react for 20 minutes, wash 3 times with isopropanol , washed 3 times with DMF, washed 2 times with re-distilled DMF, drained, added 0.7g of Fmoc-Leu-OH, 0.4ml of DIEA, 0.56g of TBTU, 0.2g of HOBT, 10ml of DMF, reacted at room temperature for 1.5 hours, and dried with a vacuum pump

Designation: RUO Research Use Only

10.1046/j.1432-1327.2000.01828.x Eur