A randomized, phase II study evaluated cediranib plus fulvestrant in postmenopausal women with hormone-sensitive metastatic breast cancer compared to placebo ( Proposed Mechanisms for the Failure of Angiogenesis Inhibitors in Breast Cancer Evidence from clinical trials constantly showed disappointing treatment outcomes for targeting VEGF/VEGFR signaling in breast cancer
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Type 2 Diabetes With Obesity CagriSema REDEFINE 2 showed 13.7% weight loss with 73.5% of T2D patients achieving HbA1c of 6.5% or less, exceeding semaglutide's glycemic and weight results in T2D trials
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