However, it has notable downsides: Cognitive side effects (brain fog, memory issues, difficulty concentrating) Can cause depression and mood instability Often leads to significant tingling sensations in the extremities Not as effective as newer weight-loss drugs Metformin Metformin is primarily used for type 2 diabetes but is sometimes prescribed off-label for weight loss due to its effects on insulin sensitivity and appetite
Anaphylaxis due to caffeine
Pharmacologic Treatment of Overweight and Obesity in Adults
MOTS-c and NAD+ keep mitochondria firing to provide energy, endurance, and muscle preservation through better fuel usage, which helps offset the fatigue, lethargy, and a general sense of unwellness sometimes accompanied due to rapid weight loss and calorie deficit
It potentially can cause pancreatitis
Scientific References Topiramate (Topamax): introduction of new safety measures including a Pregnancy Prevention Programme