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Serious toxicity is also uncommon in routine care

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This formulation utilizes Intravail technology utilizing n-dodecyl--D-maltoside (DDM) to temporarily loosen intercellular mucosal junctions, facilitating rapid systemic absorption of epinephrine even through congested nasal passages (Howell, 2024

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10.1007/s11427-023-2532-5 27 LiL.ZhaoY.DingY.GuoL.DaiR.ChenA.et al (2025)

Individual neurochemistry varies significantly, and some people simply do not respond well to DSIP regardless of protocol optimization