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The plateau typically happens somewhere between 36 and 48 weeks at maintenance doses

Eat another small meal

however, current evidence does not indicate a higher risk of infection or obesity-related cancer

Metformin commonly causes gastrointestinal upset, including nausea and diarrhea, particularly when first starting

Due to the perceived standard treatment efficacy of GLP-1 medications in blood sugar control and weight reduction, along with their cardiovascular benefits, it is expected that these medications will continue to be rapidly adopted

Newer drugs such as tirzepatide (Mounjaro, Zepbound) target GLP1 and GIP (dual agonist)