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Conclusion The oral GLP-1 analogue semaglutide is a new drug that adds several benefits to diabetes treatment in addition to blood glucose control

Rotating sites helps prevent scar tissue buildup, which can make injections more uncomfortable

Eating smaller, more frequent meals may also help

Recent work has highlighted the small intestinal microbiota as a major mediator of the gutbrain axis in regulating glucose homeostasis

Upon digestion, amino acids and peptides activate calcium-sensing and G-protein-coupled receptors on intestinal L-cells

This unresolved tension means we cannot currently say with certainty that GLP-1 therapy is universally beneficial for autoimmune conditions