Tirzepatide is a related drug that mimics GLP-1 as well as a hormone called a glucose-dependent insulinotropic polypeptide (GIP)
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A perhaps surprising appearance in the top five focus areas was Prader-Willi syndrome, which is the focus of 56 studies
1,15 Hyperglycemia-induced metabolic pathways Polyol pathway activation In a hyperglycemic state, excess glucose is shunted into the polyol pathway, where aldose reductase catalyzes its reduction to sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase
doi: 10.3389/fmicb.2022.979719
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