Several research studies with rodents fed a high-fat diet, different animal models of obesity and diabetes, and patients diagnosed with T2DM have all shown changes in gut microbiota caused by metformin, as shown in Table 1
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How much you take depends on the amount of GHK-Cu in the specific product
If you use both and want to be careful, a simple approach is to apply them at different times of day rather than mixing them in one step