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A meta-analysis of 6 studies 13,20,30,32,33,35 which attempted to estimate overall effect size of the changes from baseline in % FMD following GLP-1-based therapies could not find any significant difference between baseline and end-of-treatment samples (mean change from baseline was 0.83 [1.06, 2.73] %

At the highest dose of 12 mg, participants with type 2 diabetes achieved a mean body weight reduction of approximately 16.9% from baseline at 24 weeks

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However, a key limitation of most of these studies that reported no association is their small sample sizes and the lack of longitudinal sampling necessary to capture transient viral infections

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