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While CKD increases various uremic toxins, clinical evidence has established that indoxyl sulfate serves as an independent, powerful risk factor for cardiovascular mortality and adverse cardiovascular events (67, 68), and its levels also associate with the severity of coronary atherosclerosis (67, 69)

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Gardiner DM, Waring P, Howlett BJ (2005) The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis

Can J Biochem

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Lifestyle Factors: Smoking: Smoking can accelerate skin ageing and contribute to skin discolouration due to decreased blood flow and oxygen delivery to the skin