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Out-of-spec pH, endotoxin load, or non-pharmaceutical particulates in the water create conditions that destabilize the peptide's tertiary structure, causing aggregation and visible haze

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For most peptides, the PK and PD timescales are tightly linked: when serum concentration falls, effect diminishes

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Paris J, McConahey WM, Tausie WN, Woolner LB, Bahn RC