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The search strategy employed was as follows: (Metformin[TIAB] OR Metformin[TW]) AND (Diabetes*[Mesh] OR Diabetes*[TIAB]) AND (Osteoarthritis*[Mesh] OR Osteoarthritis*[TIAB])

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Instead of simply averaging the results, it builds a mathematical model that accounts for multiple variables at once (e.g., needle depth, frequency, treatment duration, minoxidil use)

Elevated IGF-1 levels raise concerns about potential proliferative effects on existing malignancies, making growth hormone therapy problematic for individuals with cancer history or elevated cancer risk