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In the SURPASS-4 trial, adults with T2DM at heightened cardiovascular risk, who were inadequately managed with oral glucose-lowering agents, once-weekly tirzepatide (5 mg, 10 mg, or 15 mg) were compared to insulin glargine (100 U/mL)

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[PMC free article: PMC9884337] [PubMed: 36721839] 46

For FDA-approved GLP-1 peptides, most patients notice appetite changes within the first few weeks, while measurable weight loss builds gradually over several months of consistent use