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Ohara M, Ogawa K, Suda G, Kimura M, Maehara O, Shimazaki T, Suzuki K, Nakamura A, Umemura M, Izumi T, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ohnishi S, Sakamoto N
(2) preclinical-to-clinical gaps persist in dose optimization (e.g., PK/PD modeling for febuxostatSEDDSs) and delivery route validation (e.g., human skin studies for elastic liposomes), with limited data on patient compliance and real-world applicability
Arrhythmia Trigger: In some susceptible individuals, intense exercise can trigger abnormal heart rhythms (arrhythmias)
This is because age can affect how well the body absorbs and uses B12
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