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We entered overlapping DEGs as a query signature in the CMap database and the top ten small-molecule drugs are listed in Table 1

Strauss KA, Puffenberger EG, Robinson DL, Morton DH: Type I glutaric aciduria, part 1: natural history of 77 patients

Adding to these disturbances, chronic alcohol exposure produces compensatory downregulation of GABA A receptors and upregulation of N-methyl-D-aspartate (NMDA) receptors, leading to the hyper-glutamatergic state of alcohol withdrawal (Gass and Olive 2008

This is especially important for people using semaglutide to manage diabetes or weight, as blood sugar balance is a critical factor for health

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We do not expect to generate revenue from product sales unless and until we successfully complete development and obtain regulatory approval for the marketing of one of our product candidates, which we expect will take a number of years and is subject to significant uncertainty