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Studies examining ovariectomized, hormone-primed female rats showed: Dramatic increases in solicitation behaviors (hopping, darting, ear-wiggling) at doses of 100-200 mcg/kg No effects on consummatory behaviors such as lordosis Selective enhancement of proceptive (desire-related) behaviors without affecting receptivity Effects mediated through the medial preoptic area, as direct mPOA injections replicated systemic effects These findings established PT-141 as the first pharmacological agent demonstrating selective appetitive sexual behavior enhancement in preclinical models

doi: 10.2337/db20-2216-PUB 46 BoyeKRossMModyRKonigMGelhornH

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Vitamin B12 is a water-soluble vitamin, which means that the body only absorbs as much as it needs to use and the rest is excreted in your urine