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15,16 Additionally, Phe 1 exenatide shows stronger long-term insulin release (which is dependent on -arrestin recruitment reduction), faster agonist dissociation rates and lower receptor internalization than exenatide

10.1186/s12859-018-2486-6 35

It remains under clinical investigation and has not yet received regulatory approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA)

Para aquellos que no lo conozcan, el glucagn una hormona cuyo papel principal es romper el glucgeno heptico para liberarlo al torrente sanguneo y de esta forma mantener la glucemia en un rango controlado

N Engl J Med (2022) 387(12):106374

Unlike an additive effect (1+1=2), synergy produces a result of the type 1+1=3