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Patients with swallowing difficulties, severe injection-site reactions, or other medical contraindications may require sublingual, nasal, or modified delivery systems

Substrates of casein kinase typically require a priming phosphorylation event to catalyze phosphate addition 70,71,72

This common gastrointestinal side effect occurs in approximately 8-30% of patients taking semaglutide (Ozempic, Wegovy, or Rybelsus) and is most pronounced during initial treatment and dose escalations

Do not inject intramuscularly or into bruised / inflamed tissue

Injection site reactions appear less frequently with Wegovy since youre injecting once weekly versus daily with Saxenda

Therefore, while supply of the medicine is expected to be limited for the foreseeable future, Novo Nordisk stated that a proportion of available supply will be allocated for use only within the NHS