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La evidencia sugiere que combinar estos macronutrientes en comidas balanceadas, siguiendo patrones como la dieta mediterrnea recomendada por la American Diabetes Association, puede apoyar la funcin metablica saludable y potencialmente optimizar la respuesta del GLP-1

Dysregulation of the microbiotagutbrain axis contributes to neuroinflammation, BBB disruption, protein misfolding and aggregation, and impaired neurotransmitter regulation, eventually altering neuronal survival and promoting the pathogenesis of neurodegenerative disorders [254,255]

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They are intended as adjuncts to lifestyle modifications including reduced-calorie diet and increased physical activity, not as standalone treatments

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