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It is considered a more convenient and accessible approach to provide greater comfort to patients and improve their quality of life (Dermanowski et al., 2022)

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There are various mechanisms involved in glucose homeostasis, like glucose-dependent insulin secretion, insulin biosynthesis, and glucagon regulation (34)

Another bile salts chemosensor is the nuclear farnesoid X receptor (FXR) (347) which activation, contrarily to TGR5, blocks the release of GLP-1 in the colonic L-cells (348), while in the liver induces glycogenesis helping to improve glucose homeostasis