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GLP1: the early steps of a success story

Memarpoor-Yazdi M, Zare-Zardini H, Mogharrab N, Navapour L

1 guessed that statins would increase GLP-1

Studies reveal that luteolin drastically lowers the concentrations of pro-inflammatory cytokines in lung tissues and BAL fluid, including TNF-, IL-1, and IL-6 [30, 252]

These studies additionally demonstrated that at the given doses, ascorbate plasma levels of over 10 mM could be sustained for several hours, and observed maximum achievable blood concentrations of up to 49 mM [13]

This combined systemic, direct hepatic, anti-addictive, and even anti-viral action establishes GLP-1RAs as a powerful, novel approach to reduce the cumulative toxic insults driving SLD progression across multiple etiologies