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GLP-1 receptor agonists exert neuroprotective effects primarily by inhibiting microglial activation, the primary effector cells of neuroinflammation, thus reducing the production of proinflammatory cytokines (e.g., TNF- , IL-1) and alleviating inflammatory damage to brain parenchyma

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10.1111/j.1600-0560.2009.01256.x 63 SugiharaH.YonemitsuN.MiyabaraS.YunK

Comparison of IC025 for Each GLP-1 RA in Different Age Groups of Adults

Additionally, IN delivery bypasses the gastrointestinal tract and hepatic first-pass metabolism, potentially leading to improved bioavailability of oral iron chelators like DFP (Pires et al., 2009

Melasma is complex and often requires multiple supportive strategies working together