Reasons for fatigue Fatigue stems from physical or mental factors, including things like: Metabolic conditions such as diabetes, kidney disease, Cushing syndrome, and thyroid conditions Mental health issues such as depression, stress, eating disorders, anxiety, and burnout Cardiovascular conditions affecting blood flow, such as arrhythmias, heart disease, and heart failure Medications such as antidepressants, antihistamines, steroids, statins, and sedatives Sleep problems due to insomnia, narcolepsy, jet lag, and sleep apnea Chemical imbalances due to too little or too much of various essential nutrients, vitamins, and minerals Facts about B12 deficiency Also referred to as cobalamin deficiency and named after the scientific term for this water-soluble nutrient, a B12 deficiency can result from low dietary intake or from your body not absorbing the vitamin properly

Those on immunosuppressants or with autoimmune conditions may want to discuss GHK-Cu use with healthcare providers given the peptides immune-modulating effects
Barry B
Sig Transduct Target Ther 5 , 248 (2020)
GSTM1 deletion prevalence: Approximately 4050% of individuals of European ancestry carry the GSTM1 null genotype, making it one of the most common functional gene deletions in the human genome
Temperature is not the only threat