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Treatment Options for Vitamin B12 Deficiency Treatment of vitamin B12 deficiency in the UK is guided by the underlying cause, severity of deficiency, and presence of neurological symptoms, following recommendations from NICE and the British National Formulary (BNF)

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Each compound is supplied with a comprehensive Certificate of Analysis (COA) providing qualitative and quantitative data to support transparency, traceability, and reproducibility in laboratory environments

doi:10.1176/appi.ajp.161.10.1776

Taking both together makes sense for most people, though folate status should be adequate before starting high-dose b12 to avoid masking folate deficiency