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Side Effect How Common Typically When Usually Resolves Nausea Very common First 14 weeks / dose increases Within a few weeks Diarrhoea Very common Early treatment Within a few weeks Constipation Very common Throughout treatment With hydration and fibre Reduced appetite Very common Throughout treatment Ongoing (intended effect) Vomiting Common Early treatment / dose increases Within a few weeks Fatigue / tiredness Common Early treatment / dose increases Usually within 12 weeks Dizziness Common Early treatment Usually temporary Abdominal discomfort Common Early treatment Within a few weeks Injection site reactions Common After injecting Usually within hours Headache Less common Early treatment Usually temporary Hair thinning Less common Sustained rapid weight loss Often resolves over time Pancreatitis (rare) Rare Any stage Requires immediate review A note of reassurance: The vast majority of Mounjaro side effects are mild, temporary, and manageable

closer to 0.7 indicates mostly fat.4 Shifts in RER reveal shifts in metabolic strategy: is the body burning carbs (glucose) for fuel or burning fat and, in this case, how does that change with the drug

For the most part, stretch marks will appear as a shade of red or purple

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For f , box plots show the minimum, quartiles and maximum