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In the brain, in order to induce tau phosphorylation, oxidative stress can directly interact with protein kinases, particularly glycogen synthase kinase-3 (GSK 3), increasing GSK-3 activity, which subsequently further disrupts its ability to bind to microtubules, accelerating their depolymerisation and interrupting neural signalling (48)
42 The ARC contains two distinct neuron types with opposing functions
Effects on cognitive function Effects on cognitive function The changes in PHES scores and the normalization rates of minimal and covert HE at week 24 were compared between the groups (Supplementary Table 2)
Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA
