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September 11, 2023

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Its primary function is to facilitate the transmembrane transport of extracellular cysteine and the export of intracellular glutamate, which is subsequently converted to cysteine and synthesized by GSH ( c , thereby impairing the activity of GPX4 and leading to decreased antioxidant capacity, ROS accumulation, and ferroptosis ( -mercaptoethanol (2ME), N-acetylcysteine (NAC), or vitamin E prevent cell death (49)

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