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Forward MR analysis showed that genetic prediction of increased serum vitamin B12 concentrations were robustly associated with an elevated risk of NAFLD

The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize

Effect focus: Both slow gastric emptying and increase satiety, but via complementary receptors

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Headaches: Ensure you are well hydrated and consider lowering your dose if headaches persist