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Harsh chemicals or excessive scrubbing can create irritation, which will trigger more inflammation and make dark spots darker

One cause of B12 deficiency includes pernicious anemia, a condition that results in a reduction of red blood cells when the intestines cannot absorb enough vitamin B12

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Till date, it is not totally clear whether any of these characteristic deficits is the primary initiator or just a contributor in the contemporary multifactorial AD pathology

10.1038/s41418-022-00943-y 77 LiuS.FeiW.ShiQ.LiQ.KuangY.WangC.et al (2017)

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