Hodi FS, ODay SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB et al
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No individual study had a significant effect on the pooled effect size according to the results of the sensitivity analysis at all end points
The Breast and Prostate Cohort Consortium (BPC3), a collaboration of large US and European Cohorts, genotyped a total of 1416 SNPs for 24 genes involved in the IGF-1 pathway in 6,292 Caucasian postmenopausal women with diagnosed BrCa as compared to 8,135 controls and did not find any SNP associations with BrCa risk [39]
Suggests minimal QC discipline