First, GLP-1RAs have been shown to inhibit the expression and release of proinflammatory cytokines, such as IL-6 and TNF-, thereby inhibiting the overall inflammatory response
Most of the weight lost with effective incretin therapy is fat, but patients still need a plan to preserve strength, function, and nutritional adequacy
Second, GLP-1 RAs can reduce inflammation in coronary arteries
Im going to use the SURMOUNT-5 data again as a comparison in which case the nausea rate is the same, the constipation rate is slightly better, the diarrhea rate is slightly worse and the vomiting rate similar to semaglutide but worse than tirzepatide
They can offer personalised advice on timing based on your lifestyle, work patterns, and any side effects experienced
362 In an experimental study in which osteoclast formation and bone resorption were induced in mice through lipopolysaccharide (LPS) administration, researchers discovered that simultaneous treatment with exendin-4 resulted in a significant decrease in the number of osteoclasts, the proportion of bone resorption pits, and the levels of the bone resorption marker CTX compared to injection with LPS alone