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Mechanistically, LONP1 promotes proliferation and migration of pulmonary artery smooth muscle cells by directly binding to and degrading mitochondrial pyruvate carrier 1 (MPC1), leading to pulmonary vascular remodeling and ultimately promoting the development of PH [76]

Y., Wu, H

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar purkinje cells in mice lacking Galphaq

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