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Currently, two modern effective CRISPR/Cas- and CRISPR/Cpf1-mediated genome-editing systems have been adapted for the industrial fungus A

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These strategies include the exhaustion of mutant p53 via the application of histone deacetylase (HDAC) inhibitors and heat shock protein 90 (HSP90) inhibitors to suppress tumor cell growth, blocking growth signals regulated by mutated p53

Data was graphed after normalizing each insulin time course by dividing by the secretion rate at each time point by the rate obtained in the presence of 20 mM glucose prior to the addition of test compounds

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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Varesi A., Deumer U.S., Ananth S., Ricevuti G