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AstraZeneca PLC is a biopharmaceutical company that researches, develops, manufactures, and sells prescription drugs
GLP-1 agonists can generally be used in patients with lymphoproliferative disorders, but individualised assessment is essential
The decreased in GFR or albuminuria has been associated with the presence of nonalcoholic steatohepatitis or the severity of fibrosis, whereas improvement in liver histology is associated with improvement in CKD.75 arGLP1 improves insulin levels, regulates autophagy, inhibits hepatic neoglycogenesis, reduces hepatic fat content, plasma liver enzyme levels and hepatic histological improvements have been described with liraglutide and semaglutide.49,76 Likewise, epicardial and perirenal fat are associated with increased cardiorenal risk,77 so that the reduction in ectopic fat43 as demonstrated with the use of arGLP-1 has could be beneficial in CKD
Both drugs contain the same active ingredient and are classified as glucagon-like peptide-1 (GLP-1) receptor agonists
However, no head-to-head comparative trials have been conducted , and differences in trial design, populations, and titration schedules mean direct comparisons cannot be made
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